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KMID : 1011920150160010037
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International Journal of Arrhythmia
2015 Volume.16 No. 1 p.37 ~ p.42
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Shin Seung-Yong
Im Sung-Il
Kim Jin-Seok
Lim Hong-Euy
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Abstract
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Atrial fibrillation (AF) is one of the major causes of ischemic stroke, and its incidence increases with age. Although oral anticoagulation is the standard therapy for stroke prevention in AF patients who have risk factors for thromboembolism, many of these patients do not receive anticoagulation therapy for various reasons, such as drug side effects and complications, even though new oral anticoagulants (NOACs) have now been introduced in clinical practice. In an attempt to overcome these limitations, specially designed devices with a transcatheter delivery system have been used to occlude the left atrial appendage (LAA), which has been proved to be the major source of thrombus formation in patients with non-valvular AF. Many clinical studies have demonstrated that occlusion of the LAA with devices can prevent ischemic stroke and systemic thromboembolism more safely and effectively than standard warfarin therapy. Prospective multicenter studies including AF patients with various medical conditions will be needed to prove the efficiency of LAA occlusion with devices in comparison with NOACs.
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KEYWORD
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atrial fibrillation, device, left atrial appendage
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